Preparation of β-amino compounds by Mannich reaction

February 20, 2024

• Title:       

  Preparation of β-amino compounds by Mannich reaction

• Image Source:

  Simple and new method for the synthesis of β-acetamido ketones on a solid surface

• Mark:

  Figure 1

• Associated context:

  As one of  the mostly studied MCRs, discovered in 1912, the Mannich reaction is an aminoalkylation reaction of aldehyde (Fig. 1) and is a very useful method for the preparation of β-amino compounds. β-Acetamido ketones are versatile intermediates, in that their skeletons exist in a number of biologically or pharmacologically active compounds. They could easily be converted to 1,3-amino alcohols, which are utilized for the synthesis of  several antibiotics. β-Acetamido ketones are usually prepared through acylation  of β-aminoketones, Michael addition to α,β-unsaturated ketones, or photo-isomerization of phthalimides.