Diastereoselective Mannich reaction between N-Boc-aminals 1 and aldehydes

July 26, 2024

• Title:       

  Diastereoselective Mannich reaction between N-Boc-aminals 1 and aldehydes

• Image Source:

  Brønsted acid-catalyzed Mannich reaction through dual activation  of aldehydes and N-Boc-imines

• Mark:

  Table 2

• Associated context:

  In the presence of a catalytic amount of diphenyl phosphate, the reactions of several N-Boc-aminals 1 with aldehydes afforded the corresponding anti-Mannich adducts 2 as major diastereomers (Table 2).