Mannich reaction between N-Boc-aminal 1a and 3-phenylpropanal

July 26, 2024

• Title:       

  Mannich reaction between N-Boc-aminal 1a and 3-phenylpropanal

• Image Source:

  Brønsted acid-catalyzed Mannich reaction through dual activation  of aldehydes and N-Boc-imines

• Mark:

  Table 1

• Associated context:

  The reaction of N-Boc-aminal 1a, which is known to give the corresponding N-Boc-imine and tert-butyl carbamate under acidic conditions, with 3-phenylpropanal in CH₂Cl₂ (CAS 75-09-2) did not proceed in the presence of benzoic acid (CAS 65-85-0) and its derivatives (Table 1, entries 1–3).