Brønsted acid-catalyzed Mannich reaction through dual activation

July 26, 2024

• Title:       

  Brønsted acid-catalyzed Mannich reaction through dual activation

• Image Source:

  Brønsted acid-catalyzed Mannich reaction through dual activation  of aldehydes and N-Boc-imines

• Mark:

  Scheme 1

• Associated context:

  In the presence of an acid catalyst, N-Boc-aminal is converted to N-Boc-imine (or N-Boc-iminium salt) as an activated electrophile along with the generation of tert-butyl carbamate, which might react with an aldehyde to give the corresponding enecarbamate as an activated nucleophile (Scheme 1).