Proposed strategies for the arylation of the fluorenone skeleton

February 29, 2024

• Title:       

  Proposed strategies for the arylation of the fluorenone skeleton

• Image Source:

  Chemoselective Ruthenium-Catalyzed C-O Bond Activation: Orthogonality of Nickel-and Palladium-Catalyzed Reactions for the Synthesis of Polyaryl Fluorenones

• Mark:

  Scheme 1

• Associated context:

  Herein we disclose an efficient and  straightforward methodology based on conveniently available starting materials 1 which combines DoM/DreM protocols with Ru-, Ni-and Pd-catalyzed cross-coupling reactions of C–OMe and also C–OCONR2 bonds for the regioselective synthesis of aryl fluorenones 2, isomeric 1,4- (4) and  1,8-diarylated (3), and 1,4,8-triarylated (5) fluorenones of  potential interest in material science areas (Scheme 1).