General synthesis of 1,3-diphenyl-1H-pyrazole-4-carbal-dehyde derivatives (compounds b)

February 29, 2024

• Title:       

  General synthesis of 1,3-diphenyl-1H-pyrazole-4-carbal-dehyde derivatives (compounds b)

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  Synthesis, biological evaluation, and molecular docking studies of pyrazolyl-acylhydrazone derivatives as novel anticancer agents

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  Scheme 1

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  The synthesis of compounds (1e–20e) followed the general pathway outlined in Scheme 1, the synthesis of these derivatives was started from the interaction of substituted 1,3-diphenyl-1H-pyrazole-4-carbaldehyde (compounds b) and substituted 2-((hydrazinyloxy)carbonyl)phenol (compounds d). And these starting materials were prepared in two ways,  respectively. Firstly, substituted acetophenone was interacted with phenylhydrazine hydrochloride coupled with sodium acetate in anhydrous ethanol to form compound a,  which was then added to a cold solution of DMF and POCl₃ to give the desired compound b. Secondly, substituted salylic acid was interacted with methanol, using  thionyl chloride as catalyst to yield compounds c. and then substituted compounds c reacted with 80% N₂H₄·H₂O to gain compounds d.