Identification of 3-oxodicarboxylic acids in human urine

Add time:07/23/2019    Source:sciencedirect.com

Gas chromatography-mass spectrometry has been used to detect a series of 3-oxodicarboxylic acids in human urine as their corresponding dimethyl ester trimethylsilyl enol ethers. 3-Oxohexanedioic acid, 3-oxooctanedioic acid and 3-oxodecanedioic acid were demonstrated to be normal urine constituents. Increased amounts of these acids were excreted after ingestion of decanedioic acid. These findings support the hypothesis that dicarboxylic acids are degraded by ordinary β-oxidation.

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