A novel fluorescent probe DIPHENYL-1-PYRENYLPHOSPHINE (cas 18995-02-3) to follow lipid peroxidation in cell membranes

Add time:07/22/2019    Source:sciencedirect.com

DIPHENYL-1-PYRENYLPHOSPHINE (cas 18995-02-3) (DPPP) was tested whether it could be used as a fluorescent probe to monitor lipid peroxidation in cell membranes. DPPP reacted with organic hydroperoxides and hydrogen peroxide stoichiometrically to give DPPP oxide (DPPPO). DPPP incorporated into phosphatidylcholine liposomal membranes and polymorphonuclear leukocytes (PMNs) reacted with methyl linoleate hydroperoxide rapidly but not with hydrogen peroxide nor with tert-butyl hydroperoxide. This novel method revealed that lipid peroxidation proceeded within membranes of PMNs stimulated with phorbol 12-myristate 13-acetate, which is known to produce several kinds of free radicals. It was found that DPPP is a suitable fluorescent probe to monitor lipid peroxidation within cell membranes specifically.

We also recommend Trading Suppliers and Manufacturers of DIPHENYL-1-PYRENYLPHOSPHINE (cas 18995-02-3). Pls Click Website Link as below: cas 18995-02-3 suppliers

Prev:Plasma lipid oxidation induced by peroxynitrite, hypochlorite, lipoxygenase and peroxyl radicals and its inhibition by antioxidants as assessed by DIPHENYL-1-PYRENYLPHOSPHINE (cas 18995-02-3)
Next:A phenolic antioxidant from the Pacific oyster (Crassostrea gigas) inhibits oxidation of cultured human hepatocytes mediated by DIPHENYL-1-PYRENYLPHOSPHINE (cas 18995-02-3))