Poly(glycerol adipate) – indomethacin drug conjugates – synthesis and in vitro characterization

Add time:07/21/2019    Source:sciencedirect.com

The linear biodegradable polyester poly(glycerol adipate) (PGA) was synthesized via enzymatic polycondensation using lipase B from Candida antarctica (CAL-B). Every monomer unit of PGA possesses a pendant hydroxyl group which is responsible for the hydrophilic character and moisture swelling. These OH groups were esterified to different degrees with the anti-inflammatory drug indomethacin in order to create a prodrug with a pH-sensitive linker for modified drug release. The structure of the conjugates was determined via ATR FT-IR spectroscopy, NMR spectroscopy, GPC and UV/VIS spectroscopy. The physical properties of polymers with different drug load were investigated using DSC, contact angle measurements and oscillatory rheology. Drug release was monitored over one month in vitro. A very slow, but continuous release was observed in PBS. Slightly acidic conditions and lipase activity are accelerating the indomethacin release. Therefore, poly(glycerol adipate) − indomethacin conjugates are promising prodrugs for the local sustained release of indomethacin.

We also recommend Trading Suppliers and Manufacturers of sodium hydrogen adipate (cas 18996-34-4). Pls Click Website Link as below: cas 18996-34-4 suppliers

Prev:The solubility measurements of sodium dicarboxylate salts; sodium oxalate, malonate, succinate, glutarate, and adipate in water from T = (279.15 to 358.15) K
Next:Alkali metal cation adduct effect on polybutylene adipate oligomers: Ion mobility-mass spectrometry)