Molecular design of anti-MRSA agents based on the anacardic acid scaffold

Add time:07/20/2019    Source:sciencedirect.com

A series of anacardic acid analogues possessing different side chains viz. phenolic, branched, and alicyclic were synthesized and their antibacterial activity tested against methicillin-resistant Staphylococcus aureus (MRSA). The maximum activity against this bacterium occurred with the branched side-chain analogue, 6-(4′,8′-dimethylnonyl)salicylic acid, and the alicyclic side-chain analogue, 6-cyclododecylmethyl salicylic acid, with the minimum inhibitory concentration (MIC) of 0.39 μg/mL, respectively. This activity was superior to that of the most potent antibacterial anacardic acid isolated from the cashew Anacardium occidentale (Anacardiaceae), apple and nut, that is, the 6-[8′(Z),11′(Z),14′-pentadecatrienyl]salicylic acid.

We also recommend Trading Suppliers and Manufacturers of 2-(cyclohexylethyl)boronic acid (cas 105869-43-0). Pls Click Website Link as below: cas 105869-43-0 suppliers

Prev:Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1′-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors1
Next:The coordination chemistry of 4′-(4-tert-butylphenyl)-2,2′ : 6′,2″-terpyridine—a solubilising oligopyridine)