IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance

Add time:07/22/2019    Source:sciencedirect.com

BackgroundEpidermal stem cells (ESCs) are keratinocytes that reside in the basal layer of the epidermis and mediate epidermal homeostasis. Insulin-like growth factor 1 (IGF-1) signaling through its receptor (IGF-1R) has been identified as an important regulator in rodent skin development and differentiation. However, the role of IGF-1/IGF-1R signaling in human keratinocytes is not yet well understood.

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