Hydroalkylation leading to heterocyclic compounds (Part 2): practical synthesis of polysubstituted 1,2,3,4-tetrahydropyridines through multicomponent reactions (MCRs)

Add time:07/21/2019    Source:sciencedirect.com

Polysubstituted 1,2,3,4-tetrahydropyridines were synthesized through hydroalkylation of electron-deficient alkynes, followed by double Mannich addition reactions, which is a practical protocol with atom efficiency and good substrate scope.

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