Cross-dehydrogenative coupling strategy for phosphonation and cyanation of secondary N-alkyl anilines by employing 2,3-dichloro-5,6-dicyanobenzoquinone
-
Add time:07/13/2019 Source:sciencedirect.com
The cross-dehydrogenative coupling strategy for metal-free phosphonation and cyanation of secondary N-alkyl anilines has been developed firstly under mild reaction conditions. Based on detailed optimization of reaction conditions, the substrate generality of N-alkyl anilines and various hydrogen phosphonates has been investigated, and a series of versatile α-aminophosphonates and α-aminonitriles were therefore furnished in good to excellent yields. A plausible collective reaction mechanism through dehydrogenation to imine formation, then to respective α-aminophosphonates and α-aminonitriles was proposed.
We also recommend Trading Suppliers and Manufacturers of 2-Methoxy-5-(trifluoromethyl)aniline (cas 349-65-5). Pls Click Website Link as below: cas 349-65-5 suppliers
Prev:Spectroscopic investigation of 4-nitro-3-(trifluoromethyl)aniline, NBO analysis with 4-nitro-3-(trichloromethyl)aniline and 4-nitro-3-(tribromomethyl)aniline
Next:Selective N-monomethylation of primary anilines with dimethyl carbonate in continuous flow) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- A comparative study on the properties of aromatic polyamides with methyl- or trifluoromethyl-substituted triphenylamine groups07/16/2019
- Synthesis and antimicrobial screening of 2-alkyl(aryl)-7-chloro-6-fluoro-4-(trifluoromethyl)-quinolines and their phenylacetylene derivatives, promoted by Sonogashira cross-coupling reaction07/15/2019
- Selective N-monomethylation of primary anilines with dimethyl carbonate in continuous flow07/14/2019
- Spectroscopic investigation of 4-nitro-3-(trifluoromethyl)aniline, NBO analysis with 4-nitro-3-(trichloromethyl)aniline and 4-nitro-3-(tribromomethyl)aniline07/12/2019
- A convenient synthesis of N,N-bis(trifluoromethyl)anilines07/11/2019
