Straightforward synthesis of 2-propylquinoline (cas 1613-32-7)s under multicomponent conditions in fluorinated alcohols
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Add time:07/21/2019 Source:sciencedirect.com
The synthesis of 2-propylquinolines, a family of antileishmanial agents, is reported. Among the pathways explored, the 3-component Povarov reaction between butyraldehyde, aromatic amines and ethyl vinyl ether in trifluoroethanol (TFE), followed by an oxidation, offers a convenient entry to 2-propylquinolines with various substituents on positions 5–8.
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