Determination of 2-n-propylquinoline in mouse plasma and liver by high-performance liquid chromatography

Add time:07/22/2019    Source:sciencedirect.com

A high-performance liquid chromatographic method was developed for the specific determination of 2-n-propylquinoline, a new anti-leishmaniasis drug, in plasma and liver homogenates of mice. 2-n-Propylquinoline was extracted with methyl-tert.-butyl ether with quinoline as internal standard. Separation was carried out using a Nucleosil C18 column. The mobile phase consisted of methanol–0.005 M ammonium acetate buffer (60:40) at pH 5.5 and 8 for plasma and liver homogenates, respectively. Detection was monitored at 233 nm. The method was validated and shown to be accurate and precise for plasma and liver homogenates. Extraction yield was 96% in plasma and 81% in liver homogenates. This method was used to determine the pharmacokinetic profile of 2-n-propylquinoline following oral administration to mice.

We also recommend Trading Suppliers and Manufacturers of 2-propylquinoline (cas 1613-32-7). Pls Click Website Link as below: cas 1613-32-7 suppliers

Prev:In vitro and in vivo antileishmanial properties of a 2-n-propylquinoline hydroxypropyl β-cyclodextrin formulation and pharmacokinetics via intravenous route
Next:Selection of the most promising 2-substituted quinoline as antileishmanial candidate for clinical trials)