Improved synthesis of trifluoromethyl sulfones used as intermediates for the preparation of di- or tri-substituted olefins
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Add time:07/24/2019 Source:sciencedirect.com
Primary and secondary trifluoromethyl sulfones (triflones) are efficiently obtained from easily available sodium trifluoromethanesulfinate (triflinate) and alkyl bromides in N,N-dimethylacetamide. This technique is more powerful than the potassium triflinate/acetonitrile system. Ethyl aconitate can be also produced in one step from ethyl bromoacetate and diisopropylethylamine, sodium triflinate being a catalyst.
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