HNF1A inhibition induces the resistance of pancreatic cancer cells to gemcitabine (cas 103882-84-4) by targeting ABCB1

Add time:07/20/2019    Source:sciencedirect.com

BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis, and gemcitabine (cas 103882-84-4)-based chemotherapy remains an effective option for the majority of PDAC patients. Hepatocyte nuclear factor 1α (HNF1A) is a tumor-suppressor in PDAC, but its role in gemcitabine chemoresistance of PDAC has not been clarified.

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