Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine (cas 103882-84-4) resistance by reducing intracellular gemcitabine (cas 103882-84-4) metabolites

Add time:07/22/2019    Source:sciencedirect.com

BackgroundCytosolic 5′-nucleotidase 1A (NT5C1A) dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates. Here, we investigate NT5C1A expression in pancreatic ductal adenocarcinoma (PDAC) and its impact on gemcitabine (cas 103882-84-4) metabolism and therapeutic efficacy.

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