Subcellular distribution of a labelled 2-halogenoalkylamine in guinea-pig vas deferens

Add time:07/21/2019    Source:sciencedirect.com

Guinea-pig vasa deferentia were incubated with a 2-halogenoalkylamine (14C-SY28) either alone or after exposure to the alpha receptor blocking agent, phentolamine. A quantitative evaluation was made of the distribution of the covalently bound 14C-SY28 both in lipid and lipid-free phases, and the distribution throughout the subcellular fractions of lipid-free homogenate was studied. Acid hydrolysis was carried out on each fraction and hydrolysates run on chromatography paper. Autoradiographic studies of these runs showed 14C-SY28-amino acid complexes, identical to those found previously, distributed unequally throughout the subcellular fractions. The effects of phentolamine protection of the alpha receptor, from binding by 214C-SY28 are discussed.

We also recommend Trading Suppliers and Manufacturers of 2-SY28 (cas 1214-27-3). Pls Click Website Link as below: cas 1214-27-3 suppliers

Prev:Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[ω-(benzylmethylamino)alkoxy]xanthen-9-ones
Next:Proteolipid as a binding site for 2-haloalkylamines)