Proteolipid as a binding site for 2-haloalkylamines

Add time:07/20/2019    Source:sciencedirect.com

Vasa of guinea-pigs were incubated with a 2-halogenoalkylamine [14C]Sy28 30 μM, 25 mc/m-mole, before or during exposure to 3.65 mM phentolamine, extracted with 2:1 chloroform-methanol and the extracts washed. The organic (lower) phase was subjected to hydrolysis with 6 N HCl and autoradiographs of paper chromatographs made. Three spots (in addition to the parent compound) were demonstrated in extracts of controls and two spots from phentolamine-treated tissue. SY28-amino acid complexes were compared as to Rf values and selected candidates for the binding site are discussed.

We also recommend Trading Suppliers and Manufacturers of 2-SY28 (cas 1214-27-3). Pls Click Website Link as below: cas 1214-27-3 suppliers

Prev:Subcellular distribution of a labelled 2-halogenoalkylamine in guinea-pig vas deferens
Next:2-Halogenoethylamines and the role of Ca2+ in adrenergic α-receptor activation in the rat vas deferens)