Effects of the non-peptide inhibitor OPC-21268 on oxytocin and vasopressin stimulation of rat and human myometrium
-
Add time:07/22/2019 Source:sciencedirect.com
OPC-21268 (1-[-1-[4-(3-acetylaminopropoxy)benzoyl]-piperidyl]-3,4-dihydro-2(1H)-quinolinone), a non-peptide vasopressin V1 receptor antagonist, inhibited oxytocin- and vasopressin-induced contractions of myometrial strips from rats and from full-term pregnant women. Administered intravenously in rats the drug also inhibited uterine contractions caused by infusion of oxytocin. When incubated with purified plasma membranes from rat or human myometrial tissue, OPC-21268 inhibited the specific receptor binding of tritiated oxytocin and vasopressin in a dose-dependent and reversible way.
We also recommend Trading Suppliers and Manufacturers of OPC 21268 (cas 131631-89-5). Pls Click Website Link as below: cas 131631-89-5 suppliers
Prev:Key amino acids of vasopressin V1a receptor responsible for the species difference in the affinity of OPC-21268
Next:Synthesis of N-Acetylhemiaminal metabolites of opc-21268, vasopressin V1 receptor antagonist) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Distinct Mechanisms of Action of V1 Antagonists OPC-21268 and [d(CH2)5Tyr(Me)AVP] in Mesangial Cells07/28/2019
- Effects of OPC-21268, a vasopressin V1-receptor antagonist, on expression of growth factors from glomeruli in spontaneously hypertensive rats07/27/2019
- Effect of vasopressin V1 (OPC-21268) and V2 (OPC-31260) antagonists on renal hemodynamics and excretory function07/26/2019
- Effect of a new V1 antagonist (OPC-21268) on vascular action of vasopressin in cultured rat vascular smooth muscle cells07/25/2019
- The Role of Vasopressin in Essential Hypertension07/24/2019
- Synthesis of N-Acetylhemiaminal metabolites of opc-21268, vasopressin V1 receptor antagonist07/23/2019
- Key amino acids of vasopressin V1a receptor responsible for the species difference in the affinity of OPC-2126807/21/2019
