Synthesis of N-Acetylhemiaminal metabolites of opc-21268, vasopressin V1 receptor antagonist
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Add time:07/23/2019 Source:sciencedirect.com
N-Acetylhemiaminal metabolites of 1-{1-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone (OPC-21268) (1), which is a new vasopressin V1 receptor antagonist were synthesized by oxidative decarboxylation of the corresponding α - amino acid derivatives with lead tetraacetate.
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