Enantioselective synthesis of (+)-(2S,3s)-3-ethynyltyrosine

Add time:07/21/2019    Source:sciencedirect.com

Homochiral ethynyl tyrosine 2, designed as a potential dopamine β-hydroxylase irreversible inhibitor prodrug, has been synthesised asymmetrically in 15-steps, using the alkylation and azidation of acylated oxazolidones to establish relative and absolute stereochemistry.

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