Total synthesis of nagstatin (cas 126844-81-3), an N-acetyl-β-D-glucosaminidase inhibitor

Add time:07/20/2019    Source:sciencedirect.com

The first enantiospecific total synthesis of nagstatin has been accomplished through the regioselective introduction of an allyl group on the imidazole ring of the de-branched nagstatin precursor followed by conversion into the carboxymethyl group, and the stereospecifc introduction of the acetamido group.

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