Synthesis and stability of S-cyanoethyl-protected 4-thiouridine and 2′-deoxy-4-thiouridine
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Add time:07/20/2019 Source:sciencedirect.com
A convenient preparation of S-(2-cyanoethyl) protected 2′-deoxy-4-thiouridine (5a) and 4-thiouridine (5b) is presented. The S-cyanoethyl protecting group is stable to reagents commonly encountered during the phosphoramidite method of solid-phase oligonucleotide synthesis, and is readily deprotected using concentrated NH4OH at 25°C.
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