Synthesis and biological evaluation of the L-enantiomer of 2′-deoxy-5-ethyl-4′-thiouridine
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Add time:07/22/2019 Source:sciencedirect.com
Racemic 2′-deoxy-5-ethyl-4′-thiouridine was synthesised utilising the stereoselective iodolactonisation of 3-(tert-butyldimethylsilyl)oxy-N,N-dimethyl-4-pentenamide as the key transformation. The stereo-isomeric mixture of nucleosides was resolved using HPLC on a Chiralcel OJ column. The β-d enantiomer showed potent activity against human herpesviruses while the β-l was inactive.
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