Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines

Add time:07/20/2019    Source:sciencedirect.com

Designed novel imidazo[1,2-a]pyrazine based inhibitors, synthesized by condensing α-aminopyrazines with α-halocarbonyl compounds followed by electrophilic substitutions. Cytotoxic effects on four cancer cell lines evaluated. Based on preliminary data, imidazo[1,2-a]pyrazine template redesigned to improve activity.

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