Design and optimization of the variables in the adsorptive stripping voltammetric determination of rufloxacin in tablets, human plasma and urine

Add time:07/26/2019    Source:sciencedirect.com

An adsorptive stripping voltammetric method with a hanging mercury drop electrode was developed for the determination of the fluoroquinolone rufloxacin in tablets, human plasma and urine. Measurements were obtained in differential pulse mode and a multivariate strategy was used to optimize the variables involved. Besides the independent effects of the variables, a strong interaction between scan rate and pulse duration has been found. Rufloxacin was analysed at concentrations between 1.7 × 10−8 and 1.9 × 10−7 M with a detection limit of 9.2 × 10−9 M. Diluted tablet solutions and urine samples were analysed directly, while plasma samples needed an extraction procedure before voltammetric analysis. An improved HPLC procedure was used as comparative method.

We also recommend Trading Suppliers and Manufacturers of Rufloxacin hydrochloride (cas 106017-08-7). Pls Click Website Link as below: cas 106017-08-7 suppliers

Prev:Effects of bio-compatible metal ions on rufloxacin photochemistry, photophysics and photosensitization: Copper(II)
Next:High-performance liquid chromatographic determination of rufloxacin and its main active metabolite in biological fluids)