Studies on the hypertrehalosaemic factor from the corpus cardiacum/corpus allatum complex of the beetle, tenebrio molitor

Add time:07/25/2019    Source:sciencedirect.com

1.1. The corpus cardiacum/corpus allatum complex (CC/CA) of the beetle, Tenebrio molitor, contains a factor which elicits hyperlipaemia in migratory locusts and hypertrehalosaemia in American cockroaches. Appreciable amounts of this factor are found only in the CC/CA.2.2. The lipid and carbohydrate elevations were time-dependent (maximum effect: 90 min and 120 min after injection, respectively), and were also dose-dependent. Significant hypertrehalosaemic and adipokinetic effects were obtained with 0.1 and 0.25 CC/CA equivalents, respectively; and 1.0 and 3.0 gland equivalents, respectively, were needed for maximal or near-maximal responses. lil]3. Age-related changes of both biological activities were observed in beetle CC/CA; young adults (less than 3 days after imaginai ecdysis) had smaller quantities of bioactive material stored in their CC/CA.3.4. T. molitor CC/CA extracts were also able to activate endogenous fat body glycogen phosphorylase in adult beetles in a dose-dependent manner; a maximal activation was achieved upon injection of 0.2 CC/CA equivalents.4.5. Fractionation of a methanolic extract of CC/CA by reversed-phase high performance liquid chromatography shows that the hypertrehalosaemic as well as the adipokinetic and phosphorylaseactivating activities, are probably confined to a single absorbance peak.

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