Diastereoselective syntheses of (2R,3R,5R)- and (2S,3S,5S)-3-hydroxy-5-methyl-2-pyrrolidinecarboxylic acid as a component of actinomycin Z1
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Add time:07/23/2019 Source:sciencedirect.com
A novel diastereoselective syntheses of both (2R,3R,5R)-1 and its enantiomer (2S,3S,5S)-1 were accomplished by employing trans-selective nucleophilic addition of cyanide to 3-benzoyloxy-N-acyliminium ions as the key step, starting from trans-4-hydroxy-L-proline.
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