Synthesis of enantiomerically pure (2R, 5S)- and (2R, 5R)-5-hydroxypipecolic acid from glycinate Schiff bases
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Add time:07/25/2019 Source:sciencedirect.com
An asymmetric synthesis of cis- and trans- 5-hydroxy-(D)-pipecolic acid, starting from glycinate Schiff bases is described. The approach involves the stereoselective alkylation to generate an unsaturated side chain which on cyclisation leads to the desired trans- or cis- 5-hydroxy-(D)-pipecolic acid.
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