The first asymmetric carbonylation of 1-(6′-methoxy-2′-naphthyl)ethanol to the methyl ester of (S)-naproxen
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Add time:07/14/2019 Source:sciencedirect.com
1-(6′-Methoxy-2′-naphthyl)ethanol is asymmetrically carbonylated to the methyl ester of (S)-naproxen in a PdCl2CuCl2-DDPPI (DDPPI: 1,4:3,6-dianhydro-2,5-dideoxy-2,5-bis(diphenylphosphino)-L-iditol) catalytic system with a chemical yield of 90% and an optical yield of 81% e.e.. The reaction was carried out in ethyl methyl ketone under 100°C and 8 MPa of CO for 24–48h.
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