Comparative effectiveness of three antiprogestins alone and in combination with Anordiol (cas 1045-29-0) in terminating pregnancy in the rat

Add time:07/23/2019    Source:sciencedirect.com

The effectiveness of mifepristone, onapristone, and ORG 31806 alone or in combination with Anordiol (cas 1045-29-0) to terminate pregnancy in the rat was evaluated. ORG 31806 at a dose of 2 mg/kg/day, mifepristone at 4 mg/kg/day, and onapristone at 8 mg/kg/day, terminated pregnancy in all treated animals. Anordiol, an antiestrogen, at a dose of 5 mg/kg/day, terminated pregnancy in all treated animals. Anordiol acted synergistically with all three antiprogestins terminating pregnancy in the rat. The antiprogestins at doses that were either partially effective or non-effective became 100% effective when administered with a non-effective dose of anordiol. Thus, combination of ORG 31806 (1 mg/kg/day) plus anordiol (0.31 mg/kg/day), mifepristone (1 mg/kg/day) plus anordiol (0.62 mg/kg/day), and onapristone (2 mg/kg/day) plus anordiol (2.5 mg/kg/day) terminated pregnancy in all treated animals. These combinations of the antiprogestins and anordiol decreased significantly the serum progesterone levels but not serum 17β-estradiol levels. The present results indicate that the most potent combination was ORG 31806 plus anordiol.

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