Developing a radioemmunoassay for anordrin: The synthesis of propionyl and hemisuccinyl esters of Anordiol (cas 1045-29-0)

Add time:07/27/2019    Source:sciencedirect.com

We describe the chemical synthesis of the 2β-propionate-17β-hemisuccinate and 2β-hemisuccinate-17β-propionate diesters of anordiol (2α,17α-diethynyl-A-nor-5α-androstane-2β,17β-diol) and the method for coupling them to bovine serum albumin and Affi-gel 102, in order to prepare antibodies for radioimmunoassay of anordrin. In addition, we describe the chemical synthesis of the following derivatives: 2β-ol-17β-propionate, 2β-propionate-17β-ol, 2β-hemisuccinate-17β-ol, and 2β-ol-17β-hemisuccinate.

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