Metalation of diazines XVII Very hindered bases as new metalating agents, Improvement of regioselectivity for the metalation of 3-chloro-6-methoxypyridazine

Add time:07/23/2019    Source:sciencedirect.com

The different factors governing the regioselectivity of the metalation of 3-chloro-6-methoxypyridazine with alkylamides were studied. Very hindered bases were used as new metalating agents and a very good regioselectivity was obtained.

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