Larvicidal activity of the naphthylisoquinoline alkaloid dioncophylline A (cas 60142-17-8) against the malaria vector Anopheles stephensi

Add time:07/12/2019    Source:sciencedirect.com

The larvicidal activity of dioncophylline A (cas 60142-17-8), a naphthylisoquinoline alkaloid derived from the tropical vine Triphyophyllum peltatum (Dioncophyllaceae), was investigated against the malaria vector Anopheles stephensi. In direct and indirect inhibition assays it was demonstrated that the younger larval stages were very sensitive towards this natural product, with LC50 values below 1 mg/l. Pronounced effects were observed within 4 h of exposure. Aging larvae, however, were less sensitive, while pupae were totally insensitive to the action of dioncophylline A. The transformations from larvae to pupae and from pupae to adult mosquitoes remained unaffected. Therefore, dioncophylline A can be regarded as a promising specific larvicide.

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