ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
-
Add time:07/27/2019 Source:sciencedirect.com
We recently described the purification and cloning of extracellular signal-regulated kinase 1 (ERK1), which appears to play a pivotal role in converting tyrosine phosphorylation into the serine/threonine phosphorylations that regulate downstream events. We now describe cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, and provide evidence suggesting that there are additional ERK family members. At least two of the ERKs are activated in response to growth factors; their activations correlate with tyrosine phophorylation, but also depend on additional modifications. Transcripts corresponding to the three cloned ERKs are distinctly regulated both in vivo and in a differentiating cell line. Thus, this family of kinases may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonine phosphorylation cascades. Individual family members may mediate responses in different developmental stages, in different cell types, or following exposure to different extracellular signals.
We also recommend Trading Suppliers and Manufacturers of insulin, N-Me-Ile(2A)- (cas 112659-21-9). Pls Click Website Link as below: cas 112659-21-9 suppliers
Prev:TAP2 Association with Insulin-Dependent Diabetes Mellitus Is Secondary to HLA-DQB1
Next:Neutral amino acid transport into rat skeletal muscle: Competition, adaptive regulation, and effects of insulin) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Expression of insulin-like growth factor II (IGF-II) in human primary liver cancer: mRNA and protein analysis07/29/2019
- Neutral amino acid transport into rat skeletal muscle: Competition, adaptive regulation, and effects of insulin07/28/2019
- TAP2 Association with Insulin-Dependent Diabetes Mellitus Is Secondary to HLA-DQB107/26/2019
- Identification of a novel gene encoding an insulin-responsive glucose transporter protein07/25/2019
- Effects of beef steak and cod fillet on plasma glucose, insulin, amino acids and energy metabolism in normal subjects07/24/2019
- Analogues of insulin secretagogue (2S,3R,4S)-4-hydroxyisoleucine: synthesis by 1,3-dipolar cycloaddition reactions of chiral nitrones to alkenes07/23/2019
-
Health and Chemical more >