Identification and characterization of a potent and selective inhibitor of human urate transporter 1

Add time:07/26/2019    Source:sciencedirect.com

BackgroundSelective inhibitors of human urate transporter 1 (hURAT1) are considered to be effective treatment for hyperuricemia and gout, which can reduce the reabsorption of more than 90% of uric acid in the proximal tubule of the kidney. We aimed to design and synthesize a more potent hURAT1 based on the structure of Lesinurad (LU), which was reported to lower uric acid levels with IC50 value of hURAT1 (about 60 μM).

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