Enzymatic desymmetrization of meso-2,3-bis(acetoxymethyl) and bis(hydroxymethyl) substituted hexachloronorbornadiene derivatives
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Add time:07/26/2019 Source:sciencedirect.com
meso-Bis(acetoxymethyl)-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hepta-2,5-diene and meso-bis(hydroxymethyl)-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hepta-2,5-diene were transformed into chiral monoesters with 65–92% ee via enzymatic desymmetrization using various lipases. The absolute configuration was determined by transforming 2-acetoxymethyl-3-hydroxymethyl-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hepta-2,5-diene into the 2-acetoxymethyl-3-hydroxymethylbicyclo[2.2.1]hepta-2,5-diene of known absolute configuration.
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