Induction of chromosomal aberrations in Chinese hamster ovary cells by triethyllead acetate

Add time:07/30/2019    Source:sciencedirect.com

Organolead compounds enter the environment primarily through the combustion of leaded gasoline and industrial discharge. Lead and lead-containing compounds have been shown to induce a broad spectrum of toxic effects, including hematopoetic, renal, neurologic, and carcinogenic effects. In this study, the mutagenic activity of triethyllead acetate (Et3PbAc) was determined by measuring the induction of chromosomal aberrations in Chinese hamster ovary cells. The results indicate that Et3PbAc is very cytotoxic and a potent clastogen. In preliminary cytotoxicity studies used to determine appropriate test concentrations for chromosomal aberration analysis, the LC50 of Et3PbAc was approximately 10 μM in the absence of metabolic activation, and 80 μM in the presence of metabolic activation. Et3PbAc induced a significant (p < 0.01) increase in chromosomal aberrations at 6 μM in the absence of metabolic activation, and 40 μM in the presence of metabolic activation. The maximal response was greater with metabolic activation than without. However, a much higher dose was required to elicit a significant response in the presence of metabolic activation than in its absence.

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