Comparison of the inhibition by methylmercury and triethyllead of galactolipid accumulation in rat brain

Add time:08/01/2019    Source:sciencedirect.com

Methylmercury chloride (MeHg) and triethyllead chloride (Et3Pb) interfere with the myelin deposition in young rats. In order to establish how myelin synthesis and development are affected by these neurotoxins, we have investigated the synthesis of myelin galactolipids using two different systems: (1) slices of cerebellum from 2-week-old rats, (2) enzyme preparations from rat brain. MeHg (50 μm) or Et3Pb (5 μm) gave maximum inhibition of the uptake of 35SO4 by sulfatides (63%). The [3H]serine uptake by cerebrosides with normal unsubstituted fatty acids (NFA) was inhibited up to 45% at 70 and 7 μm of MeHg and Et3Pb, respectively, after incubation of the slices for 16 hr in an Eagle basal medium at 37°C. At the same concentrations the inhibition of [3H]serine uptake in cerebrosides with α-hydroxy fatty acids (HFA) was about 35%. MeHg (50–100 μm) inhibited UDPgalactose:ceramide galactosyltransferase (CGalT) and phosphoadenosine-5′-phosphosulfate:cerebroside sulfotransferase (CST) activities up to 50%, while the inhibition with Et3Pb was about 30% at 2.5 mm for the enzymes.

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