Decarboxylative dipropargylation of primary amines with propiolic acids and formaldehyde via metal-free coupling

Add time:07/24/2019    Source:sciencedirect.com

A metal-free decarboxylative coupling reaction, which produced important and useful dipropargylic amines, was developed under mild conditions. This novel methodology showed a broad range of functional-group compatibility for primary amines and propiolic acids, and gave the corresponding products in up to 97% yields.

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