Synthesis of mannostatins A and B from myo-inositol

Add time:07/24/2019    Source:sciencedirect.com

Mannostatins A and B, along with the respective enantiomer and diastereoisomer having the (S)-sulfinyl function, were synthesized from myo-inositol. Inhibitory activity of the synthetic compounds against jack bean α-mannosidase was measured, revealing that the 4-aminocyclopentane-1,2,3-triol structure plays a major role in interaction with the enzyme.Mannostatins A and B, together with the respective enantiomer and diastereoisomer having the (S)-sulfinyl function, were synthesized from myo-inositol. Inhibitory activity of the synthetic compounds against jack bean α-mannosidase was measured.

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