Methanesulfenyl triflate promoted iminosulfenylation of an allylic trichloroacetimidate. An efficient and stereospecific total synthesis of (+) mannostatin A

Add time:07/26/2019    Source:sciencedirect.com

The stereospecific synthesis of glycoprotein processing enzyme inhibitor (+) mannostatin A 1 was achieved in ten steps from D-ribonolactone 9 (∼ 39% overall yield). The strategy featured methanesulfenyl triflate mediated intramolecular cyclization of allylic N-sufenylimidate 12.

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