Chiral high-performance liquid chromatographic analysis of enantiomers of Losigamone (cas 112856-44-7), a new candidate antiepileptic drug
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Add time:07/30/2019 Source:sciencedirect.com
An assay based on a single-step liquid–liquid extraction from human plasma followed by high-performance liquid chromatography on a chiral column was developed for the measurement of enantiomers of a racemic new candidate antiepileptic drug. Excellent intra- and inter-assay accuracy and precision and recovery were demonstrated in the desired concentration range of 0.031 to 5.00 μg/ml. The method is free from interferences by other anticonvulsant drugs and their metabolites. The method is being used in a clinical trial of losigamone.
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