Analysis of chlorinated acetic and propionic acids as their pentafluorobenzyl derivatives I. Preparation of the derivatives

Add time:07/27/2019    Source:sciencedirect.com

Pentafluorobenzyl (PFB) derivatives of chlorinated acetic and propionic acids were prepared adapting previously published methods to prepare PFB derivatives of non-chlorinated acids. Reaction of monochloro- and dichloroacetic acids and 2-chloro-, 2,2-dichloro- and 2,3-dichloropropionic acids with pentafluorobenzyl bromine (PFBBr) produced the PFB esters. Trichloroacetic acid reacted with PFBBr to give 1,1,1-trichloro-2-pentafluorophenylethane. On standing, this was partly degraded to 1,1-dichloro-2-pentafluorophenylethene. Gas chromatography-mass spectrometry, 1H NMR and 13C NMR were used to determine the structures of the derivatives.

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