Induction of hepatic peroxisomes by a new, non-carboxylate-eontaining drug, bifonazole

Add time:07/26/2019    Source:sciencedirect.com

The acute effect of an antimycotic drug, bifonazole, on hepatic peroxisomes of rats was studied in comparison with that of clotrimazole, which has a similar structure. By feeding 0.5% bifonazole in the diet for 5 days, the activities of camitine acyltransferase, carnitine palmitoyltransferase and the peroxisomal β-oxidation system were increased by 30-, 3- and 7-fold, respectively, over the control. Under the same conditions, clotrimazole did not cause such changes. Electron microscopic observation showed that peroxisome proliferation had been induced by bifonazole treatment. Thus, a compound which does not contain a carboxylate moiety can induce peroxisomes in rodent liver.

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