Studies towards 4-C-alkylation of pyridin-2(1H)-one derivatives

Add time:07/25/2019    Source:sciencedirect.com

In order to obtain 4-C-alkylated pyridin-2(1H)-ones, two strategies were studied: nucleophilic substitution of 4-chloro-3-nitropyridinone derivatives which essentially failed and lithiations of 2-methoxy-3-pivaloylaminopyridines which gave the expected products.

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