The microbiological hydroxylation of 3,16-Disubstituted androstanes by cephalosporium aphidicola

Add time:07/25/2019    Source:sciencedirect.com

5α-Androstane-3, 16-dione has been prepared by hydroboration and oxidation of 3β-hydroxy-5α-androst-16-ene. Reduction with sodium borohydride gave the 3β, 16β-diol. The fungus Cephalosporium aphidicola has been shown to hydroxylate 5α-androstane-3, 16-dione predominantly at the C-6β position with minor hydroxylation occurring at the C-7α and C-14α positions. In contrast hydroxylation of the 3β, 16β-diol took place at C-11α. The 3β-hydroxy-16α, 17α-epoxide was hydroxylated at the C-6β position.

We also recommend Trading Suppliers and Manufacturers of 17-BETA-HYDROXY-5-ALPHA-ANDROSTANE (cas 1225-43-0). Pls Click Website Link as below: cas 1225-43-0 suppliers

Prev:Prostatic tissue distribution of 17β-hydroxy-5α-Androstan-3-one (cas 1224-95-9) and of androgen receptors in benign hyperplasia
Next:Determination of doxepin and DESMETHYLDOXEPIN (cas 1225-56-5) in human plasma using liquid chromatography–tandem mass spectrometry)