A tandem and tunable Pd catalyzed C–N coupling of heteroarenols with ureas via C–OH bond activation

Add time:07/27/2019    Source:sciencedirect.com

At this circumstance for the first time, a facile and convenient method for heteroaryl ureas has been developed via a two-step process involving in situ C–OH activation followed by palladium catalyzed C–N coupling of heteroarenols with ureas, which show excellent functional group tolerance and give out rapid coupling in good to excellent yield.

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